Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivitySARS-CoV-2 변이체 B.1.617 분석: 숙주 친화성, 단백질 분해 활성화, 세포-세포 융합 및 중화 민감도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity Adenovirus adenovirus vaccine Amino acid B.1.617 caused cell-cell fusion cell–cell fusion cells Characteristics Convalescent patients COVID-19 pandemic D614G variant Delta escaped furin host tropism human cells immunized inactivated Inactivated vaccine India Infection Infectivity L452R mAbs Mutation mutations neutralization neutralization activities neutralization activity neutralization. pathogenicity proteolytic activation pseudotyped pseudotyped virus Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera T478K Transmissibility transmitted variant variants viruses volunteers [DOI] 10.1080/22221751.2022.2054369 PMC 바로가기 [Article Type] Article
The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variantsArticle Published on 2022-11-082022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% CI Accuracy Alpha variant Amino acid Analysis B.1.1.529 B.1.1.7 cause Del detect evaluated genomic Laboratory Mutation omicron positive Positive predictive value Protein resulting RT-PCR S gene SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variant Sensitivity and specificity sequenced Sequencing spike gene TaqPath tested the Spike Thermo Fisher variant variants of concern VoC [DOI] 10.1038/s41598-022-21564-y PMC 바로가기
From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force fieldArticle Published on 2022-11-012022-11-16 Journal: Journal of computer-aided molecular design [Category] 유전자 메커니즘, [키워드] Abraham Affect alteration Amino acid Antibody neutralization antiviral drugs biological activity calculate complexes Donald evaluated example glycoprotein Intramolecular stability LogPo/w mechanism of action modulation mutated Mutation mutations oncoprotein pharmacological polymorphism Protein Proteins Scoring Scoring function. single nucleotide spike stability susceptibility viral replication [DOI] 10.1007/s10822-022-00477-y PMC 바로가기
Genomic and epidemiologic surveillance of SARS-CoV-2 in Southern Brazil and identification of a new Omicron-L452R sublineageArticle Published on 2022-11-012022-11-16 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] Amino acid B.1.1.529 Brazil Characteristics COVID-19 cases delta variant dominant Epidemiologic surveillance epidemiological data Genetic increase in information knowledge mutated Mutation mutational scanning omicron pandemic replaced Research resulting S:L452R SARS-CoV-2 the SARS-CoV-2 variant VoC VOC. [DOI] 10.1016/j.virusres.2022.198907 PMC 바로가기
Geographical distribution of SARS-CoV-2 amino acids mutations and the concomitant evolution of seven distinct clades in non-human hostsArticle Published on 2022-11-012022-11-16 Journal: Zoonoses and Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid analysed Analysis antigenicity clade Combination country Denmark distribution early stage Efficacy epidemiological Evolution exhibiting GISAID globe Host human SARS-CoV-2 indicate Latvia Local moderate MOST Mutation mutations Netherlands Non-human Non-human hosts ORF10 ORF3a pandemic pathogenicity Proteome evolution raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. sequence Seven Surveillance sustained the SARS-CoV-2 genome the vaccine Transmissibility transmissions USA variant viral evolution Viral transmission viral variant Whole-genome sequence zoonotic zoonotic transmission [DOI] 10.1111/zph.12971 PMC 바로가기
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical centerArticle Published on 2022-11-012022-11-16 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] Amino acid amino acid variation cause cerebrospinal fluid children collected Complication COVID-19 COVID-19 infection diagnosed Encephalitis Epidemic explain immunological incidence increase in Infection Inflammatory marker Lineage medical record Mutation N-terminal domain nasal swab neurological Neurological complication Neurological symptom Neurological symptoms omicron Patient pediatric pediatric cases Pediatric patient Pediatric patients positive Protein reported SARS-CoV-2 sequence Sequencing Severe neurological symptoms spike Spike protein Strains Taiwan tested the S protein variant Variation viral genome analysis whole genome Whole genome sequencing whole genome sequencing. with COVID-19 [DOI] 10.1016/j.ijid.2022.09.001 PMC 바로가기
Case report: BA.1 subvariant showing a BA.2-like pattern using a variant-specific PCR assay due to a single point mutation downstream the spike 69/70 deletionArticle Published on 2022-10-272022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy Algorithm Amino acid amplification BA.1 BA.4 BA.5 Cluster COVID-19 pandemic database detect diagnostic downstream epidemiological example faster genomic knowledge melting curve analysis Mutation mutations next generation sequencing Next-generation sequencing NGS omicron over overcome PCR PCR assay Point mutation probe SARS-CoV-2 SARS-CoV-2 variant sequence Spain specific mutation Surveillance temperature time-consuming variant Variant-specific PCR. while [DOI] 10.1186/s12985-022-01883-2 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontologyArticle Published on 2022-10-212022-11-16 Journal: Journal of Biomedical Semantics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine vaccine. variant variants variants of SARS-CoV-2 virus [DOI] 10.1186/s13326-022-00279-z PMC 바로가기
Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States미국 조지아주 샘플에서 SARS-CoV-2 게놈의 돌연변이 역학 분석Article Published on 2022-10-202022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Amino acid analysis Analysis caused China clade clades Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 country Course COVID-19 D614G determine disease England Europe Filter Genome genome sequence Genome sequences Host indicate limit majority Multiple Multiple studies mutated Mutation N501Y NCBI database Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide nucleotides online tool over P681H pandemic Phylogenetic Quality control reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sequence Sequence alignment sequenced genomes sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2. Spread state survival the United State the WHO translation Transmission variant variants virus was used Wuhan [DOI] 10.1016/j.gene.2022.146774 PMC 바로가기 [Article Type] Article